BU-308 Systems Biology

Unit · year 3

BU-308 · Systems Biology

Threads systems · regulation23 lectures4 concepts

Understanding biology as networks rather than isolated parts.

PREREQUISITES

L01	Why Systems? The Limits of Reductionism Emergent properties
L02	Networks in Biology Gene regulatory networks
L03	Gene Regulatory Networks Gene regulatory networks
L04	Network Motifs Gene regulatory networks
L05	The Feed-Forward Loop Gene regulatory networks
L06	Modelling Transcriptional Dynamics Gene regulatory networks
L07	Negative Feedback and Homeostasis Feedback loops in biology
L08	Positive Feedback and Bistability Feedback loops in biology
L09	Feedback Loops in Biology Feedback loops in biology
L10	Oscillators: Circadian Rhythms Feedback loops in biology
L11	Robustness and Fragility Feedback loops in biology, Emergent properties
L12	Metabolic Networks Metabolic flux analysis
L13	Stoichiometric Modelling Metabolic flux analysis
L14	Metabolic Flux Analysis Metabolic flux analysis
L15	Flux Balance Analysis and Optimality Metabolic flux analysis
L16	Constraint-Based Prediction Metabolic flux analysis
L17	Emergent Properties Emergent properties
L18	Emergence Across Biological Scales Emergent properties
L19	Noise and Stochasticity in Cells Gene regulatory networks
L20	Omics Data and Integration —
L21	Model Organisms as Systems —
L22	Whole-Cell Models Emergent properties
L23	Synthesis: The Whole and Its Parts Gene regulatory networks, Emergent properties

The logic of cellular decision-making.

Sources of robustness and oscillation.

Tracing material flow through a metabolic network.

Behaviour arising from interactions, not parts.