Unit · year 3
BU-307 · Cancer Biology
Threads regulation · information25 lectures5 concepts
Cancer as a disease of the genome and of evolution within the body.
Lectures
| L01 | Cancer as a Genetic Disease — |
| L02 | Tumour Types and Progression — |
| L03 | Proto-Oncogenes and Oncogenes |
| L04 | Mechanisms of Oncogene Activation |
| L05 | Tumour Suppressor Genes |
| L06 | The Two-Hit Hypothesis |
| L07 | p53: The Guardian of the Genome |
| L08 | The Cell Cycle Revisited |
| L09 | Cyclins and Cyclin-Dependent Kinases |
| L10 | The G1/S Checkpoint and Rb |
| L11 | The G2/M and Spindle Checkpoints |
| L12 | DNA Damage Response |
| L13 | The Hallmarks of Cancer |
| L14 | Sustained Proliferative Signalling |
| L15 | Evading Growth Suppression and Apoptosis |
| L16 | Replicative Immortality and Telomerase |
| L17 | Reprogrammed Metabolism: The Warburg Effect |
| L18 | Angiogenesis |
| L19 | Invasion and the Metastatic Cascade |
| L20 | The Tumour Microenvironment |
| L21 | Clonal Evolution of Tumours |
| L22 | Intratumour Heterogeneity |
| L23 | Therapy Resistance as Evolution |
| L24 | Targeted Therapy and Immunotherapy |
| L25 | Synthesis: Cancer as Somatic Evolution |
Concepts in this unit
T-097
Oncogenes and tumour suppressors
The genetic accelerators and brakes of cancer.
T-098
The hallmarks of cancer
The capabilities a tumour must acquire.
T-099
Cell cycle checkpoints
Surveillance that guards against damaged division.
T-100
Angiogenesis and metastasis
How tumours secure a blood supply and spread.
T-101
Clonal evolution of tumours
Cancer progression as natural selection.