BU-204 Population & Molecular Genetics

Unit · year 2

BU-204 · Population & Molecular Genetics

Threads information · evolution24 lectures5 concepts

How allele frequencies change, and why.

PREREQUISITES

L01	From Individuals to Gene Pools —
L02	Allele and Genotype Frequencies The Hardy-Weinberg principle
L03	The Hardy–Weinberg Principle The Hardy-Weinberg principle
L04	Assumptions of Hardy–Weinberg The Hardy-Weinberg principle
L05	Using Hardy–Weinberg as a Null Model The Hardy-Weinberg principle
L06	Testing for Deviation from Equilibrium The Hardy-Weinberg principle
L07	Selection Acting on Allele Frequency Mutation-selection balance
L08	Mutation as a Source of Variation Mutation-selection balance
L09	Mutation–Selection Balance Mutation-selection balance
L10	Heterozygote Advantage: Sickle Cell Mutation-selection balance
L11	Genetic Drift: The Idea Genetic drift
L12	Effective Population Size Genetic drift
L13	Founder Effects Genetic drift
L14	Population Bottlenecks Genetic drift
L15	Drift versus Selection: Which Dominates? Genetic drift
L16	Gene Flow and Migration Gene flow
L17	Gene Flow as a Homogenising Force Gene flow
L18	Population Structure and F-Statistics Gene flow, Inbreeding and heterozygosity
L19	Non-Random Mating Inbreeding and heterozygosity
L20	Inbreeding and Loss of Heterozygosity Inbreeding and heterozygosity
L21	Inbreeding Depression Inbreeding and heterozygosity
L22	Conservation Genetics of Small Populations Genetic drift, Inbreeding and heterozygosity
L23	Quantitative Genetics and Heritability —
L24	Synthesis: The Forces That Change Gene Pools The Hardy-Weinberg principle, Genetic drift

Allele and genotype frequencies in an idealised population.

Random sampling changes allele frequencies.

Migration mixes alleles between populations.

Why harmful alleles persist at low frequency.

The genetic cost of mating with relatives.