Unit · year 4
BU-404 · Molecular Medicine
Threads regulation · structure24 lectures4 concepts
The molecular basis of disease and its treatment.
Lectures
| L01 | Molecular Medicine: The Premise — |
| L02 | Drug Targets and Druggability |
| L03 | Receptor Pharmacology |
| L04 | Agonists, Antagonists, and Partial Agonists |
| L05 | Affinity, Efficacy, and Potency |
| L06 | Competitive and Non-Competitive Antagonism |
| L07 | Dose–Response Relationships |
| L08 | The EC50 and the Sigmoid Curve |
| L09 | Therapeutic Index and Safety Margin |
| L10 | Quantal Dose–Response and Population Variation |
| L11 | Absorption and Bioavailability |
| L12 | Distribution and Volume of Distribution |
| L13 | Metabolism and First-Pass Effect |
| L14 | Excretion and Clearance |
| L15 | Half-Life and Dosing Regimens |
| L16 | Compartmental Pharmacokinetic Models |
| L17 | Genetic Variation and Drug Response |
| L18 | Pharmacogenomics |
| L19 | Genomic Medicine |
| L20 | Genome-Wide Association Studies |
| L21 | Monogenic and Polygenic Disease |
| L22 | Biomarkers and Stratified Medicine |
| L23 | Drug Discovery and the Development Pipeline |
| L24 | Synthesis: From Molecule to Patient |