Unit · year 3
CU-305 · Advanced Organic Synthesis
Threads structure · kinetics25 lectures5 results
Designing and controlling the construction of complex molecules.
PREREQUISITES
Lectures
| L01 | The Synthetic Problem — |
| L02 | Retrosynthetic Analysis |
| L03 | Disconnections and Synthons |
| L04 | Functional Group Interconversion |
| L05 | Choosing a Strategic Bond |
| L06 | Carbon–Carbon Bond Formation: An Overview — |
| L07 | Enolate Chemistry and the Aldol Reaction — |
| L08 | The Claisen Condensation — |
| L09 | Organometallic Reagents: Grignard and Organolithium — |
| L10 | Pericyclic Reactions and Orbital Symmetry |
| L11 | The Diels–Alder Reaction |
| L12 | Regio- and Stereochemistry of Diels–Alder |
| L13 | Frontier Orbitals and Reactivity |
| L14 | Protecting Group Strategy |
| L15 | Protecting Alcohols, Amines, and Carbonyls |
| L16 | Orthogonal Protection |
| L17 | Stereoselectivity: The Vocabulary |
| L18 | Substrate and Reagent Control |
| L19 | Asymmetric Catalysis |
| L20 | Chiral Auxiliaries |
| L21 | Transition-Metal Cross-Coupling |
| L22 | Suzuki, Heck, and Sonogashira Couplings |
| L23 | The Catalytic Cycle |
| L24 | Total Synthesis: A Case Study |
| L25 | Synthesis: Planning Backwards, Building Forwards |
Results in this unit
T-092
Retrosynthetic analysis
Planning a synthesis by working backwards from the target.
T-093
The Diels-Alder reaction
A concerted, stereospecific cycloaddition.
T-094
Protecting group strategy
Masking reactivity to control a synthesis.
T-095
Stereoselective synthesis
Controlling which stereoisomer is formed.
T-096
Transition-metal cross-coupling
Forming carbon-carbon bonds catalytically.