Unit · year 2
CU-206 · Organic Reaction Mechanisms
Threads kinetics · structure26 lectures6 results
The arrow-pushing logic behind how organic reactions actually proceed.
Lectures
| L01 | Curly Arrows: The Language of Mechanism — |
| L02 | Nucleophiles, Electrophiles, and Leaving Groups — |
| L03 | Bond Homolysis and Heterolysis — |
| L04 | Carbocations, Carbanions, and Radicals — |
| L05 | Reaction Energy Profiles |
| L06 | Intermediates versus Transition States |
| L07 | The Hammond Postulate |
| L08 | Kinetic versus Thermodynamic Control |
| L09 | Nucleophilic Substitution: The SN2 Mechanism |
| L10 | Stereochemistry of SN2 |
| L11 | The SN1 Mechanism |
| L12 | Factors Favouring SN1 or SN2 |
| L13 | Elimination: The E2 Mechanism |
| L14 | Zaitsev and Hofmann Products |
| L15 | The E1 Mechanism |
| L16 | Substitution versus Elimination |
| L17 | Electrophilic Addition to Alkenes |
| L18 | Markovnikov's Rule and Carbocation Stability |
| L19 | Rearrangements and Anti-Markovnikov Routes |
| L20 | Aromatic Stability and Reactivity |
| L21 | Electrophilic Aromatic Substitution |
| L22 | Directing Effects of Substituents |
| L23 | Nucleophilic Addition to Carbonyls |
| L24 | Addition–Elimination at the Acyl Carbon |
| L25 | Enols, Enolates, and Alpha-Substitution |
| L26 | Synthesis: Mechanism Predicts Product |
Results in this unit
T-059
SN1 and SN2 substitution
Two contrasting routes for nucleophilic substitution.
T-060
E1 and E2 elimination
Forming alkenes by loss of a leaving group.
T-061
Electrophilic addition and Markovnikov's rule
Regiochemistry of addition to alkenes.
T-062
Electrophilic aromatic substitution
Directing and activating effects on the benzene ring.
T-063
Nucleophilic addition to carbonyls
The reactivity of the carbon-oxygen double bond.
T-064
Reaction energy profiles
Intermediates, transition states and the rate-determining step.