Unit · year 4
CU-402 · Chemical Biology & Biochemistry
Threads structure · kinetics25 lectures5 results
The molecular chemistry underpinning living systems.
Lectures
| L01 | The Molecules of Life: An Overview — |
| L02 | Amino Acids and the Peptide Bond — |
| L03 | Protein Secondary Structure — |
| L04 | Tertiary and Quaternary Structure — |
| L05 | Protein Folding Thermodynamics |
| L06 | The Hydrophobic Effect |
| L07 | Denaturation and the Folding Funnel |
| L08 | Nucleic Acids: Structure |
| L09 | DNA Base Pairing |
| L10 | The Double Helix and Its Stability |
| L11 | Melting Temperature and Hybridisation |
| L12 | Enzymes as Catalysts — |
| L13 | Michaelis–Menten Kinetics |
| L14 | Deriving the Michaelis–Menten Equation |
| L15 | KM, Vmax, and kcat |
| L16 | Lineweaver–Burk and Modern Fitting |
| L17 | Competitive Inhibition |
| L18 | Non-Competitive and Uncompetitive Inhibition |
| L19 | Irreversible Inhibitors and Drug Design |
| L20 | Allosteric Regulation and Cooperativity — |
| L21 | ATP and Free-Energy Coupling |
| L22 | Coupled Reactions in Metabolism |
| L23 | Redox Cofactors and Electron Transport |
| L24 | Membranes and Chemiosmosis |
| L25 | Synthesis: Life as Controlled Chemistry |
Results in this unit
T-114
Michaelis-Menten kinetics
Enzyme rate as a function of substrate concentration.
T-115
Enzyme inhibition
Competitive and non-competitive kinetic signatures.
T-116
Protein folding thermodynamics
The free-energy balance of the native state.
T-117
DNA base pairing
Hydrogen bonding and the double helix.
T-118
ATP and free-energy coupling
Driving unfavourable reactions with a favourable one.